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Long COVID and ME/CFS may share many symptoms, but they don’t always respond the same way. In this discussion, Tapley Holland explains that many people with Long COVID experience rapid improvements in inflammation, energy, pain, and sensory symptoms following TruDOSE treatment. Patients with ME/CFS often improve as well, but their recovery may require more treatments because the illness has developed through multiple layers over time. This distinction highlights an important principle in personalized medicine: similar diagnoses do not always represent the same biological state. By recognizing where a patient is in their recovery journey, treatment can be better matched to their current needs. Key Insights